Coexistence of Cheilitis Glandularis and Lichen Planus: Remarkable Response to Anti-inflammatory Treatments

A 36‐year‐old female patient presented with gradually enlarging and painful bleeding of her lower lip within 20 years. The patient did not define mechanical irritation, smoking, atopic state, chronic sun exposure, or photosensitivity. She was on oral antidiabetic treatment for Type 1 diabetes mellitus for 5 years. She did not have xerophthalmia, xerostomia, or arthritis. Organomegaly, lymphadenopathy, or palpable mass or any glandular involvement such as submandibular, sublingual, lacrimal, and parotid glands were not detected. Dermatological examination revealed fine desquamation, lacy white streaks, dilated and erythematous multiple milimetric ductal openings, and mild serous discharge by palpation [Figure 1]. There was no vermilion or adjacent skin involvement. A wedge resection biopsy of the lower lip showed epidermal keratinization, granular layer, apoptotic cells lined in the basal layer, and lichenoid inflammation. Chronic lymphocytic inflammation of the minor salivary glands, periductal dense lymphocytic inflammation, and mild ductal ectasia were detected in the dermis [Figure 2]. The inflammatory infiltrate in the tissue did not contain any plasma cells staining with CD138. Periodic acid Schiff/alcian blue (PAS/AB) staining did not show any dermal mucin or thick basal membrane. Fibrosis and obliterative phlebitis within the tissue were not present.